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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Ononin, Paclitaxel
Phytochemical Name Ononin (PubChem CID: 442813 )
Anticancer drug Name Paclitaxel (PubChem CID: 36314 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Paclitaxel
Adverse Reactions Bronchospasmodic dyspnoea, hypotension, peripheral neuropathy and bone, joint and muscle aches and pains. This was inferred cold nature anticancer drug.
Recommendations Hot: Dimocarpus longan; Terminalia chebula; Astragalus membranaceus; Lycopodium japonicum
Reference Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022.　　ref_link
Combination Pair ID: 135
Ref_1
Pair Name Ononin, Paclitaxel
Disease Info [ICD-11: 2C25.Z] Lung cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Phosphorylation PIK3CB KEGG ID N.A.
Down-regulation Phosphorylation AKT1 hsa207
Down-regulation Expression MTOR hsa2475
Down-regulation Expression RELA hsa5970
Down-regulation Expression CDH2 hsa1000
Down-regulation Expression MMP2 hsa4313
Down-regulation Expression MMP9 hsa4318
In Vivo Model A549 cells (5×10⁹/mL) were inserted subcutaneously into each mouse's flank.
Result Our findings suggested that the therapeutic index of PTX-based chemotherapy could be improved by reducing toxicity with increasing antitumor capabilities when combined with ononin.
03. Reference
No. Title Href
1 Antitumor Effects of Ononin by Modulation of Apoptosis in Non-Small-Cell Lung Cancer through Inhibiting PI3K/Akt/mTOR Pathway. Oxid Med Cell Longev. 2022 Dec 27;2022:5122448. doi: 10.1155/2022/5122448. Click
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